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Pure Wellness Medical Supplements

PURE Wellness Immune Booster

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$60.50 USD
Regular price
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$60.50 USD
  • Description
  • Serving: 1 scoop (12.2g)   90 servings per container    Flavor: Fruit Punch

    Directions: As a dietary supplement, Mix 1 scoop with 16-20 ounces of water daily.

    BENEFITS: Provides immune support, reduces inflammation and optimizes full-body wellness. Our special blend of nutrients contains powerful antioxidants and immune modulators that enhance the body’s resistance.



    IMPORTANT FACTS:

    ALPHA-LIPOIC ACID: Regulates and supports the immune system, while also suppressing inflammation.

    GLUTAMINE: Aids in unique metabolic functions to regulate metabolism and fuel cells.

    ZINC: Necessary for proper immune cell function and cell signaling.

    VITAMIN C: Releases oxidizing agents that play a role in the deactivation of viruses and the killing of bacteria.

    GARLIC: Strengthens and supports the immune system by stimulating immune cells.

    MONOLAURIN: Most powerful little-known supplement. Fights yeast, bacteria (especially staph aureus), Lyme’s Disease, and most importantly viruses.

    TUMERIC(CURCUMIN) & GINSENG: Potent immune modulators that strengthen our nonspecific and specific (antibody) immune responses.

     

  • Clinical evidence
  • Αlpha-lipoic acid [ALA] is a natural ingredient of human body, not only acts as a powerful antioxidant but also is able to regulate the immune system in either direct or indirect ways (1). ALA might have immunomodulatory effects on both adaptive and innate immune systems (1). Studies reviewed above might suggest that ALA is used to treat autoimmune diseases including SLE, RA, and primary vasculitis as well as MS (1). The current therapies for systemic rheumatic diseases are effective (1). ALA is a cofactor for α-ketoglutarate dehydrogenase complex to protect mitochondria from oxidative attack. Role of Oxidative Stress [ROS] may have a physiological role in signal transduction of all kinds of immune cells. ALA increase cAMP synthesis through activation of prostaglandin receptors [EP2 and EP4] in peripheral blood T cells. ALA could suppress production of interferon-γ [IFN-γ] and interleukin -4 [IL-4]. Studies demonstrated the beneficial effects of ALA on treating experimental autoimmune encephalomyelitis by suppressing the infiltration of inflammatory cells (2-5). It highly implied that ALA showed immunomodulatory effects on differentiation and proliferation of T cells (4). It has also been found that ALA regulated activation, phagocytosis, and migration of macrophage by either direct or indirect means (6). Consuming Green Tea or its active ingredient, epigallocatechin-3-gallate [EGCG], has been shown consistently to benefit the healthy functioning of several body systems. In the immune system specifically, accumulating evidence has revealed an immunomodulating effect of green tea/EGCG (7). EGCG given to autoimmune encephalomyelitis [EAE] mice, an animal model for human multiple sclerosis [MS], reduced the clinical symptoms, brain pathology, and proliferation and TNF-α production of encephalitogenic T cells (7). The protective effect of EGCG is associated with the suppressed proliferation of autoreactive T cells, reduced production of pro-inflammatory cytokines, decreased Th1 and Th17, and increased Treg populations in lymphoid tissues and central nervous system (7). Recent studies have also highlighted the critical role of Th17/Treg balance in the pathogenesis of rheumatoid arthritis [RA] (7). EGCG has been shown to be anti-inflammatory and protective in several studies using animal models of inflammatory arthritis (7). Garlic supplements are known to boost the function of the immune system (8). Josling performed a double-blind study that showed overwhelmingly garlic as a preventive measure, demonstrating accelerated relief, reduction in the severity of troublesome symptoms such as sneezing, cough and runny nose, and recovery to full fitness (8). He found that a daily garlic supplement reduced the number of colds by 63% compared to a placebo and the average length of cold symptoms was also reduced by 70%, from 5 days in the placebo group to just 1.5 days in the garlic group (8). This study also showed a reduced likelihood of becoming reinfected with other viral strains and demonstrated general improvement of the immune system (8). Another study found that a high dose of aged garlic extract reduced the number of days sick with cold or flu by 61% (9). Glutamine is the most abundant and versatile amino acid in the body (10). It is of and is of fundamental importance to intermediary metabolism, interorgan nitrogen exchange via ammonia (NH3) transport between tissues, and pH homeostasis (10). Glutamine is considered as a “fuel for the immune system”, where a low blood concentration may impair immune cell function, resulting in poor clinical outcomes and increased risk of mortality (10). Although glucose is a vital metabolite, and the main fuel for a large number of cells in the body, cells of the immune system, such as lymphocytes, neutrophils, and macrophages, utilize glutamine at high rates similar to or greater than glucose under catabolic conditions, such as sepsis, recovery from burns or surgery, and malnutrition, as well as high intensity/volume physical exercise (11,12). Tumeric and its main active compound Curcumin are traditionally known for their anti-inflammatory effects (13). During the last 2 decades curcumin has been shown to be a potent immunomodulatory agent that can modulate the activation of T cells, B cells, macrophages, neutrophils, natural killer cells, and dendritic cells (13). Curcumin can also downregulate the expression of various proinflammatory cytokines including TNF, IL-1, IL-2, IL-6, IL-8, IL-12, and chemokines, most likely through inactivation of the transcription factor NF-κB (13). Even at low doses curcumin can enhance antibody responses (13). Curcumin’s ability to modulate the immune system has shown beneficial effects in arthritis, allergy, asthma, atherosclerosis, heart disease, Alzheimer’s disease, diabetes, and cancer (13). Baik et al. looked at Ginseng and partially purified ginsenoside extract to evaluate their antioxidant, anti-inflammatory and antithrombotic effects (14). The study found reduced nitric oxide levels and reduced pro-inflammatory cytokines, such as tumor necrosis factor-α, interleukin [IL]-1β and IL-6 (14). Another study found ginseng extract could enhance the effect of vaccinations against diseases like influenza, as well (15). One study by Lieberman and colleagues showed that
    some viruses that were were inactivated by Monolaurin include measles, Herpes simplex-1, vesicular stomatitis, visna virus, and cytomegalovirus (16). In addition, a number of fungi, yeasts, and protozoa are reported to be inactivated or killed by monolaurin, including several species of ringworm (16). This study also showed Candida albicans and the protozoan parasite Giardia lamblia were both reported to be killed by monolaurin (16). Ezigbo et al. showed that Monolaurin destroys lipid coated viruses by binding to the lipid protein envelope of virus thereby preventing it from attaching and entering host cells, this kills the viral envelope seen as no growth sign in our observations, thereby killing the virus (17). Monolaurin has been shown through a study by Thormar et al. to affect the viral envelope, causing leakage and at higher concentrations, a complete disintegration of the envelope and the viral particles (18). They also caused disintegration of the plasma membranes of tissue culture cells resulting in cell lysis and death (18). One study by Kabara shown Monolaurin is the most inhibitory saturated fatty acid against gram-positive bacteria (19). This study also demonstrated Monolaurin to be effective against gram negative bacteria (19). Beuchat and colleagues in a study showed that monolaurin had a strong enhancing effect on the thermal destruction of E. coli and P. aeruginosa (20). Goc and colleagues in a study showed Monolaurin has been found to be the most effective antimicrobial compounds against all morphological forms of the two tested Borrelia species that cause Lyme’s Disease (21). Ruzin et al. in a study showed Monolaurin inhibits the expression of virulence factors in Staphylococus aureus and the induction of vancomycin resistance in Enterococcus faecalis, presumably by blocking signal transduction (22). Projan and colleagues showed that monolaurin inhibits the synthesis of most staphylococcal toxins and other exoproteins (23). Shankar et al. in one study showed Zinc to be crucial for normal development and function of cells mediating nonspecific immunity such as neutrophils and natural killer cells (24). They also found Zinc deficiency to affect development of acquired immunity by preventing both the outgrowth and certain functions of T lymphocytes such as activation, Th1 cytokine production, and B lymphocyte help. The study also showed B lymphocyte development and antibody production, particularly immunoglobulin G, to be compromised with Zinc deficiency (24). They showed how the macrophage, a pivotal cell in many immunologic functions, is adversely affected by zinc deficiency, which can dysregulate intracellular killing, cytokine production, and phagocytosis (24). Shankar et al. explained zinc to be a key immunologic mediator that is rooted in the myriad roles for zinc in basic cellular functions such as DNA replication, RNA transcription, cell division, and cell activation (24). Zinc also functions as an antioxidant and can stabilize membranes (24). Vitamin C is an efficient water-soluble antioxidant. Therefore, any effects of vitamin C may be most prominent under conditions when oxidative stress is elevated. Many infections lead to the activation of phagocytes, which release oxidizing agents referred to as reactive oxygen species [ROS] (26). These play a role in the processes that lead to the deactivation of viruses and the killing of bacteria (26). Vitamin C may protect host cells against the actions of ROS released by phagocytes. Phagocytes have a specific transport system by which the oxidized form of vitamin C [dehydroascorbic acid] is imported into the cell where it is converted into the reduced form of vitamin C (27,28). Increased ROS production during the immune response to pathogens can explain the decrease in vitamin C levels seen in several infections. There is evidence that plasma, leukocyte and urinary vitamin C levels decrease in the common cold and in other infections (25,31). Hume and Weyers [1973] reported that vitamin C levels in leukocytes halved when subjects contracted a cold and returned to the original level one week after recovery (32). Vitamin C levels are also decreased by pneumonia (33,34,35,36). Decreases in vitamin C levels during various infections imply that vitamin C administration might have a treatment effect on many patients with infections. Vitamin C levels in white blood cells are tens of times higher than in plasma, which may indicate functional roles of the vitamin in these immune system cells. Vitamin C has been shown to affect the functions of phagocytes, production of interferon, replication of viruses, and maturation of T-lymphocytes, etc. in laboratory studies (25,31,37,38,39). In 1970, Linus Pauling, a Nobel laureate in chemistry and also a Nobel Peace Prize winner, wrote a book on vitamin C and the common cold (40). He also published two meta-analyses, which were among the earliest meta-analyses in medicine (41,42). Pauling identified calculated that there was strong evidence that vitamin C decreased the “integrated morbidity” of colds (41). Pauling et al. over several studies concluded that gram doses of vitamin C would be beneficial against colds (40,41,42). A meta-analysis by Hemilä [1996] showed that there was very strong evidence from the five studies that colds were shorter or less severe in the vitamin C groups, and therefore those studies corroborated Pauling’s hypothesis that vitamin C was indeed effective against colds (44).

  • References
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    2. Marracci G. H., Jones R. E., McKeon G. P., Bourdette D. N. Alpha lipoic acid inhibits T cell migration into the spinal cord and suppresses and treats experimental autoimmune encephalomyelitis. Journal of Neuroimmunology. 2002;131(1-2):104–114. 
    3. Morini M., Roccatagliata L., Dell'Eva R., et al. Alpha-lipoic acid is effective in prevention and treatment of experimental autoimmune encephalomyelitis. Journal of Neuroimmunology. 2004;148(1-2):146–153. 
    4. Wang K.-C., Tsai C.-P., Lee C.-L., et al. α-lipoic acid enhances endogenous peroxisome-proliferator-activated receptor-γ to ameliorate experimental autoimmune encephalomyelitis in mice. Clinical Science. 2013;125(7):329–340. 
    5. Schreibelt G., Musters R. J. P., Reijerkerk A., et al. Lipoic acid affects cellular migration into the central nervous system and stabilizes blood-brain barrier integrity. The Journal of Immunology. 2006;177(4):2630–2637. 
    6. Van Der Goes A., Brouwer J., Hoekstra K., Roos D., Van Den Berg T. K., Dijkstra C. D. Reactive oxygen species are required for the phagocytosis of myelin by macrophages. Journal of Neuroimmunology. 1998;92(1-2):67–75. 
    7. Dayong Wu, Junpeng Wang, Munkyong Pae, Simin Nikbin, Meydani. Green tea EGCG, T cells, and T cell-mediated autoimmune diseases. Molecular Aspects of Medicine Volume 33, Issue 1, February 2012, Pages 107-118
    8. Peter Josling, B.Sc. Preventing the Common Cold With a Garlic Supplement: A Double-Blind, Placebo Controlled Survey. Adv Ther. Jul-Aug 2001;18(4):189-93. 
    9. Meri P Nantz, Cheryl A Rowe, Catherine E Muller, Rebecca A Creasy, Joy M Stanilka, Susan S Percival. Supplementation with aged garlic extract improves both NK and T cell function and reduces the severity of cold and flu symptoms: a randomized, double-blind, placebo-controlled nutrition intervention. Clin Nutr. 2012 Jun;31(3):337-44.  
    10. Vinicius Cruzat, Marcelo Macedo Rogero, Kevin Noel Keane, Rui Curi, Philip Newsholme. Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation. Nutrients. 2018 Nov; 10(11): 1564. Published online 2018 Oct 23. 
    11. Newsholme P. Why is l-glutamine metabolism important to cells of the immune system in health, postinjury, surgery or infection? J. Nutr. 2001;131:2514S–2523S. 
    12. Cruzat V.F., Krause M., Newsholme P. Amino acid supplementation and impact on immune function in the context of exercise. J. Int. Soc. Sports Nutr. 2014;11:61. 
    13. Ganesh Chandra Jagetia, Bharat B Aggarwal. "Spicing up" of the immune system by curcumin J Clin Immunol. 2007 Jan;27(1):19-35.  
    14. In-Hee Baik, Kyung-Hee Kim, Kyung-Ae Lee. Antioxidant, Anti-Inflammatory and Antithrombotic Effects of Ginsenoside Compound K Enriched Extract Derived from Ginseng Sprouts. Molecules. 2021 Jul; 26(13): 4102. 
    15. F Scaglione, G Cattaneo, M Alessandria, R Cogo. Efficacy and safety of the standardized Ginseng extract G115 for potentiating vaccination against the influenza syndrome and protection against the common cold. Drugs Exp Clin Res. 1996;22(2):65-72.  
    16. Lieberman S, Enig MG, Preuss HG. A Review of Monolaurin and Lauric Acid Natural Virucidal and Bactericidal Agents. Alternative & Complimentary Therapies, December 2006. 12(6): 310-314.
    17. Ezigbo, Veronica O., Mbaegbu Emmanuella A. Extraction of Lauric Acid from Coconut Oil, Its Applications and Health Implications On Some Microorganisms. African Journal of Education, Science and Technology, April, 2016 Vol 3, No. 2 p144-147
    18. Thormar H, Isaacs CE, Brown HR, Barshatzky MR, Pessolano T. Inactivation of enveloped viruses and killing of cells by fatty acids and monoglycerides. AntimicrobialAgents and Chemotherapy. 1987 Jan;31(1):27-31.
    19. Kabara JJ, Swieczkowski DM, Conley AJ, Truant JP. Fatty acids and derivatives as antimicrobial agents. Antimicrobial Agents and Chemotherapy. 1972 Jul;2(1):23-8.
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    23. Projan SJ, Brown-Skrobot S, Schlievert PM, Vandenesch F, Novick RP. Glycerol monolaurate inhibits the production of beta-lactamase, toxic shock toxin-1, and other staphylococcal exoproteins by interfering with signal transduction. Journal of Bacteriology. 1994 Jul;176(14):4204-9.
    24. A H Shankar, A S Prasad. Zinc and immune function: the biological basis of altered resistance to infection. Am J Clin Nutr 1998 Aug;68(2 Suppl):447S-463S. doi: 10.1093/ajcn/68.2.447S.
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